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Buy Synjardy (Metformin Hydrochloride, Empagliflozin) Online
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Drug Information
Synjardy (empagliflozin/metformin HCl) is a prescription fixed-dose combination therapy used to improve blood sugar (glucose) control in adults with type 2 diabetes. With several options for initiating, titrating and maintaining the correct Synjardy dosage and usage, this medication supports daily diabetes care alongside diet and exercise. You can consult your doctor about the right dose.
Quick Facts Table
| Attribute | Details |
| Drug Name | Synjardy (empagliflozin plus metformin) |
| Drug Class | Combination therapy (SGLT2 inhibitor and Biguanide) |
| Dosage Forms | 5mg/500mg; 5mg/850mg; 5mg/1000mg; 12.5mg/850mg; 12.5mg/500mg; 12.5mg/1000mg options available |
| Primary Indications | Type 2 diabetes (adjunct to diet and exercise) |
| Prescription Required | Yes |
| Shipping Region | United States |
What is Synjardy?
Synjardy is a medication that combines two different drugs in a single tablet to help manage type 2 diabetes through complementary mechanisms of action. It is not intended for the treatment of type 1 diabetes.
Drug Overview and Benefits
Synjardy works through a dual mechanism of action to manage blood sugar:
- Empagliflozin: An SGLT2 (sodium-glucose co-transporter 2) inhibitor that works by helping the kidneys remove glucose from the bloodstream through urine.
- Metformin Hydrochloride: A biguanide that lowers glucose production in the liver and improves the body’s sensitivity to insulin.
Together, these components provide robust glycemic control and offer potential benefits for weight and cardiovascular health.
Indications
Synjardy is used as an adjunct to diet and exercise to improve glycemic control in adults with type 2 diabetes. It is also indicated to reduce the risk of cardiovascular death in patients with type 2 diabetes and established cardiovascular disease.
How to Use Synjardy – Dosage & Administration
Following the prescribed Synjardy dosage is critical for its effectiveness and safety. Your doctor will determine the right dose for you based on your patient’s current regimen and renal function.
Starting and Maintenance Dosage
The starting dose is individualized. For patients not currently on either empagliflozin or metformin, the recommended starting Synjardy dosage is typically a lower strength taken twice daily. Your healthcare provider will adjust the dose based on your response and tolerance, up to the maximum recommended dose.
Administration Instructions
Take the Synjardy tablet with meals twice daily as prescribed to reduce the risk of gastrointestinal adverse reactions associated with the metformin HCl component. Adhering to the dosing schedule is essential for the medication’s effectiveness.
Missed Dose and Refill Guidance
If you have a missed dose, take it as soon as you remember. However, if it is almost time for your next dose, skip the missed one. Never take a double dose. You can renew your prescription and order a refill from a trusted pharmacy online with a valid prescription.
Side Effects and Safety Information
Before starting this drug, discuss your medical history and all other medications with your doctor or pharmacist.
Common Side Effects
Common side effects of Synjardy include:
- Urinary tract infections and yeast infections
- Increased thirst and more frequent urination
- Nausea, diarrhea and upset stomach
- Headache
Serious Risks
Serious side effects can occur. Seek medical attention if you experience symptoms of:
- Lactic Acidosis: A rare but serious condition associated with metformin with symptoms like muscle pain, confusion and rapid breathing. The risk is higher in patients with renal impairment or prolonged fasting.
- Diabetic Ketoacidosis (rare): A serious condition where the body produces high levels of blood acids called ketones.
- Dehydration (Volume Depletion): Can lead to a sudden drop in blood pressure and kidney problems.
Is Synjardy Safe?
Synjardy is generally well-tolerated when used as prescribed and with appropriate monitoring. It is crucial to assess renal function before starting and periodically during treatment. Caution is advised for elderly patients and those with kidney problems.
Synjardy for Type 2 Diabetes
Synjardy plays a key role in a comprehensive diabetes management plan. It not only improves glycemic control but also offers benefits related to body weight and cardiovascular outcomes, making it a valuable option for many adults with type 2 diabetes.
Synjardy vs Metformin
While metformin is a first-line treatment for type 2 diabetes, Synjardy offers a dual-action advantage. The addition of empagliflozin provides enhanced blood sugar-lowering effects, promotes the removal of excess glucose and offers cardiovascular benefits that metformin monotherapy does not.
Synjardy Interactions
Inform your doctor of all medications you take. Key drug interactions to be aware of include:
- Diuretics: May increase the risk of dehydration and low blood pressure
- Insulin or Insulin Secretagogues: May increase the risk of hypoglycemia (low blood sugar)
- Drugs that Interfere with Metformin Clearance: Such as ranolazine, vandetanib, dolutegravir and cimetidine
Synjardy and Insulin
Synjardy can be used with insulin but this combination may increase the risk of low blood sugar. Your doctor may need to lower your insulin dose. Close monitoring of blood glucose is essential when co-administering these medications.
Synjardy Weight Management
While some patients may experience modest weight loss, Synjardy is not a weight-loss drug. Any effect on weight is a secondary benefit. Glycemic control through diet and exercise remains the primary goal of your treatment plan.
Synjardy Indications and Usage
Synjardy is indicated for adults with type 2 diabetes to improve blood sugar control. It is often prescribed for patients who need more than just metformin and can benefit from its dual action and cardiovascular advantages.
Synjardy vs Other Combination Therapies
Compared to other SGLT2 inhibitor and metformin combination therapies, Synjardy’s empagliflozin component has strong clinical data supporting its efficacy in reducing cardiovascular risk. The choice between therapies depends on the individual patient’s clinical profile, including renal function and cardiovascular history.
Synjardy Dosing by Renal Function
Synjardy dosing by renal function is a critical consideration. Your doctor will evaluate your kidney health before prescribing this medication. The dose may need to be adjusted and Synjardy is contraindicated in patients with severe renal impairment.
Safety Profile of Synjardy
The overall safety profile of Synjardy is well-established. Common adverse events are generally mild and manageable. Key risk mitigation strategies include patient education on the signs of lactic acidosis, ketoacidosis and dehydration, along with regular monitoring by a healthcare provider.
References and Editorial Review
The information on this page is based on clinical studies and peer-reviewed medical journals. All content is written and reviewed by certified medical experts and is regularly updated to reflect the latest research and guidelines to ensure accuracy.
Legal & Medical Disclaimer
This content is for informational purposes only and should not replace professional medical advice. Synjardy is a prescription medication that must be used under the supervision of a healthcare professional. Always talk to your doctor before starting or stopping any therapy.
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Frequently Asked Questions
What is Synjardy and how does it work?
Synjardy is a prescription medication for type 2 diabetes that combines empagliflozin and metformin. It works by removing sugar through urine and reducing the liver's sugar production.
What are the starting doses and how is titration done?
The starting dose depends on your current treatment and will be determined by your doctor, who will gradually adjust it based on effectiveness and tolerability.
What are the common side effects and what serious risks exist?
Common side effects include urinary tract infections, increased urination, and nausea. Serious risks include lactic acidosis and ketoacidosis.
How does Synjardy compare with metformin alone?
Synjardy provides greater blood sugar reduction and offers additional cardiovascular and weight benefits compared to metformin monotherapy.
What are common drug interactions to watch for?
Interactions with diuretics, insulin, and certain other drugs can affect safety and effectiveness. Always inform your doctor of all medications you are taking.
Can Synjardy be used with insulin?
Yes, but it requires careful monitoring for low blood sugar and your insulin dose may need to be adjusted by your doctor.
What lifestyle factors maximize benefit and minimize risk?
A healthy diet, regular exercise and staying hydrated are essential to maximize the benefits of Synjardy and reduce risks like dehydration and lactic acidosis.
How to get Synjardy online and refill prescriptions?
You can order Synjardy online with a valid prescription from a licensed healthcare provider through our affiliated pharmacies.
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