Buy Contrave (Naltrexone HCl/Bupropion HCl) Online

Contrave (naltrexone HCl/bupropion HCl) is a prescription-only weight management medication designed for adults who are obese or overweight and have weight-related medical problems. When used with a reduced-calorie diet and increased physical activity, Contrave helps you lose weight.

Quick Facts Table

What Is Contrave?

Contrave is a prescription medicine for chronic weight management in adults. It is not intended to treat depression or other mental illnesses, nor is it used for smoking cessation. This medication is a tool to support your weight loss journey as part of a comprehensive treatment plan that includes diet and exercise.

Drug Components and Mechanism

Contrave combines two medications in one extended-release tablet:

• Naltrexone Hydrochloride: An opioid antagonist.
• Bupropion Hydrochloride: An aminoketone antidepressant.

While the exact neurochemical effects are not fully understood, Contrave is believed to work on two key areas of the brain: the hypothalamus (appetite regulatory center) to reduce hunger and the mesolimbic dopamine circuit (reward system) to help control cravings.

Approved Uses

Contrave is indicated for adults with:

• A body mass index (BMI) of 30 kg/m² or greater (obese).
• A body mass index (BMI) of 27 kg/m² or greater (overweight) who also have at least one weight-related medical problem, such as high blood pressure, type 2 diabetes, or high cholesterol.

How Contrave Supports Weight Loss

Contrave helps you lose excess weight by targeting the underlying factors of hunger and cravings, which are often barriers to successful weight loss.

Appetite Suppression and Craving Reduction

Contrave’s dual-action formula helps patients regain control over their eating habits.

• Reduces Hunger: By acting on the appetite center in the brain, it can help you feel less hungry throughout the day, making it easier to stick to a lower-calorie diet.
• Controls Cravings: It helps manage cravings for certain foods, reducing the impulse for emotional eating and helping you make healthier food choices.

Clinical Trial Evidence

In clinical studies, patients who took Contrave in combination with diet and exercise lost more weight than those who used diet and exercise alone. After one year, many patients achieved significant weight loss and were better able to maintain their results. Your healthcare provider can discuss if these results are relevant to your weight loss goals.

Dosage & Administration

It is essential to take Contrave exactly as prescribed by your healthcare provider. The dosage is increased gradually to help your body adjust and to minimize side effects.

Starting Dosage and Schedule

The recommended dosing schedule involves a gradual increase over four weeks:

• Week 1: One tablet in the morning.
• Week 2: One tablet in the morning and one in the evening.
• Week 3: Two tablets in the morning and one in the evening.
• Week 4 and onward: Two tablets in the morning and two in the evening.

How to take

You should swallow the tablets whole. Do not cut, chew or crush them.

• Avoid high-fat meals when taking your dose, as this can increase your risk of seizures.
• Your healthcare provider will evaluate your progress after 12 weeks on the full dose to determine if Contrave is the right treatment plan for you.

Missed Dose and Tapering

If you miss a dose, skip it and take the next dose at its regular time. Do not take an extra tablet to make up for the missed dose. Do not abruptly stop taking Contrave without consulting your doctor.

Side Effects, Warnings and Precautions

Before you take Contrave, discuss your full medical history with your doctor, including any other medications, herbal supplements or over-the-counter medicines you use.

Common Side Effects

The most common side effects include:

• Nausea
• Constipation
• Headache
• Vomiting
• Dizziness
• Insomnia or trouble sleeping
• Dry mouth

Serious Precautions

Contrave has a boxed warning because it contains bupropion, which may increase the risk of suicidal thoughts and behaviors, particularly in children, teenagers and young adults.

• You and your family should monitor for any changes in mood, thoughts or behavior and report them to your doctor immediately.
• Your healthcare provider should screen you for bipolar disorder, as Contrave can trigger manic episodes.
• Contrave can cause an increase in blood pressure and heart rate.

Drug Interactions and Contraindications

Do NOT take Contrave if you:

• Have uncontrolled high blood pressure.
• Have a seizure disorder.
• Are taking other medicines that contain bupropion (such as Wellbutrin or Zyban).
• Have or have had an eating disorder like anorexia or bulimia.
• Are dependent on opioid pain medicines, use street drugs, or are in opiate withdrawal. Using Contrave with opioids can lead to sudden opioid withdrawal.
• Are taking monoamine oxidase inhibitors (MAOIs).

Ordering Process

Our process is designed to be simple, secure and supportive.

1. Select Your Medication
2. Complete Checkout
3. Upload Your Prescription

Know more about how to order medications.

References and Editorial Review

The information on this page is based on clinical studies and peer-reviewed medical journals. All content is written and reviewed by certified medical experts and is regularly updated to reflect the latest research and guidelines to ensure accuracy and trustworthiness.​

Legal & Medical Disclaimer

This content is for informational purposes only and is not a substitute for professional medical advice from a qualified healthcare provider. A prescription is mandatory to order Eliquis. Always consult your doctor or pharmacist with any questions about your medical condition or treatment.​