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Pioglitazone Hydrochloride
Pioglitazone is an oral medication belonging to the thiazolidinedione (TZD) class of drugs, prescribed for the management of type 2 diabetes in adults. Its primary function is to improve the body’s sensitivity to insulin, a natural hormone that helps control blood sugar levels.
Quick Facts Table
| Attribute | Details |
| Drug Name | Pioglitazone (Pioglitazone Hydrochloride) |
| Drug Class | Thiazolidinedione (TZD) |
| Dosage Forms | 15 mg, 30 mg, 45 mg oral tablets |
| Indications | Type 2 diabetes mellitus |
| Prescription Required | Yes |
| Shipping Region | United States |
What is Pioglitazone?
Pioglitazone is a prescription medication used to control blood sugar levels in patients with type 2 diabetes. It helps the body use its own insulin more effectively, thereby lowering blood sugar levels. It is not for treating type 1 diabetes.
As an adjunct to a proper diet and regular exercise, this medication helps the body use insulin more effectively to manage blood glucose. It may be used as a standalone therapy or in combination with other diabetes medications, such as metformin or insulin, as part of a comprehensive treatment approach.
Drug Overview and Benefits
Pioglitazone works by making your body respond better to insulin, the hormone that regulates blood sugar. It helps to decrease the amount of glucose your liver makes and increases glucose uptake by your muscles, allowing your body to use sugar more efficiently. This medication should be used along with a proper diet and exercise program.
Indications
Pioglitazone is FDA-approved to improve glycemic control in adult patients with type 2 diabetes. It can be used alone or in combination with other medications for diabetes.
Dosage & Administration
It is important to follow the pioglitazone dosage guide and your doctor’s instructions for the best results.
Tablet Strengths and Typical Dosages
Pioglitazone is available in 15 mg, 30 mg, and 45 mg tablets. The starting dose is usually 15 mg or 30 mg once daily. Your doctor may increase your dose up to 45 mg once daily based on how you respond to the treatment.
How to Take Pioglitazone
Take this medication by mouth, with or without food, as directed by your doctor, usually once daily. Take it with a full glass of water at the same time each day.
Refill and Storage Instructions
You can get a pioglitazone refill online with a valid prescription. Store the tablets at room temperature, away from moisture and heat.
Side Effects and Safety Information
Before you begin taking pioglitazone, consult your healthcare provider about your medical history and all other medications you are taking.
Common Side Effects
The most common pioglitazone side effects include:
- Headache
- Muscle pain
- Weight gain
- Cold-like symptoms
Serious Warnings
Pioglitazone has a boxed warning for the risk of congestive heart failure. It can cause your body to retain extra fluid (fluid retention), which can lead to swelling (edema) and weight gain.
Contact your doctor immediately if you experience shortness of breath, unusual weakness, or swelling in your ankles or legs. There is also a potential increased risk of bladder cancer. Report any blood in your urine to your doctor right away. Regular monitoring for liver disease is also important.
Drug Interactions
Pioglitazone drug interactions can affect how it works. Inform your pharmacist about all the drugs you use, especially CYP2C8 inhibitors, insulin, and other diabetes drugs.
Is Pioglitazone Safe?
It is generally safe when used as prescribed and with regular monitoring by a healthcare provider. However, it is contraindicated in patients with established New York Heart Association (NYHA) Class III or IV heart disease and should be used with caution in others with heart conditions.
Pioglitazone and Metformin Combination
The pioglitazone and metformin combination is a common and effective treatment plan. Using these two drugs together can enhance glycemic control in patients who are not able to achieve sufficient control on either medication alone.
Ordering and Prescription Process
You can buy Pioglitazone online safely and securely using a valid prescription from your doctor. Here is our simple ordering process:
- Select Your Medication
- Complete Checkout
- Upload Your Prescription
References and Editorial Review
The information on this page is based on clinical studies and peer-reviewed medical journals. All content is written and reviewed by certified medical experts and is regularly updated to reflect the latest research and guidelines to ensure accuracy and trustworthiness.
Legal & Medical Disclaimer
This content is for informational purposes only and is not a substitute for professional medical advice from a qualified healthcare provider. A prescription is mandatory to order Pioglitazone. Always consult your doctor or pharmacist with any questions about your medical condition or treatment.
Citations

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