Zepbound Cost: $1,086 Monthly List + $25 Copay Savings Guide

According to Lilly’s official pricing information, the list price of Zepbound is $1,086 per month for a 28-day supply (4 pre-filled pens). This applies to all dosage strengths from 2.5 mg to 15 mg. However, your actual monthly costs depend on insurance coverage, discount eligibility, and how you access care. 

The medication is administered as a once-weekly injection, typically prescribed in combination with a reduced-calorie diet and increased physical activity for chronic weight management.

TL;DR: Zepbound Cost Summary 2026

• The cost of Zepbound without insurance is approximately $1,086 per month for pre-filled pens. 
• However, cash-paying patients can access single-dose vials through LillyDirect starting at $299 for the 2.5 mg dose and $449 for higher doses (7.5-15 mg). 
• With commercial drug insurance and the Zepbound Savings Card, eligible patients may pay as low as $25 for a one- or three-month supply. 
• Medicare beneficiaries will gain access to Zepbound at a $50 monthly copay starting mid-2026 under the Trump administration’s GENEROUS program. 
• In Canada, Zepbound costs CAD$300-420 (approximately USD$217-300) following December 2025 price cuts.

Zepbound Price Without Insurance USA

Without insurance, the average retail list price for a one-month supply of Zepbound is approximately $1,060-$1,500, depending on pharmacy location. Paying cash at retail pharmacies means facing these high out-of-pocket expenses. However, Eli Lilly offers significant savings programs through LillyDirect, the company’s direct-to-consumer platform.

As of December 1, 2025, Zepbound single-dose vials can be purchased at reduced prices through LillyDirect, starting at $299 for the 2.5 mg dose and $399 for the 5 mg dose. For higher doses (7.5 mg, 10 mg, 12.5 mg, and 15 mg), Lilly offers a 1-month supply for $449 each through the Zepbound Self Pay Journey Program. 

These vial prices represent savings of 60-75% compared to the list price of pre-filled pens. Vials require patients to draw medication with a syringe, but your healthcare provider can show you the proper technique.

Zepbound Cost With Insurance 2026

Insurance coverage for weight-loss medications like Zepbound varies widely across health insurance plans. Zepbound is rarely covered by insurance when prescribed solely for weight loss, and most plans require prior authorization before approving coverage. If you have commercial drug insurance with coverage for Zepbound, you may be eligible to pay as low as $25 for a one- or three-month supply using the Zepbound Savings Card.

If your commercial insurance does not cover Zepbound, you may still be eligible for savings. The Zepbound Savings Card can lower the cost to as low as $499 for a 1-month supply of Zepbound single-dose pens (maximum savings of $620 per fill and $8,060 annually). The Zepbound Savings Card is not available for patients covered by government insurance programs, such as Medicare, Medicaid, TRICARE or VA benefits.

If your plan does not include coverage for Zepbound, your healthcare provider can submit an appeal letter on your behalf to request an exception based on medical necessity. Since Zepbound is approved for treating moderate-to-severe obstructive sleep apnea in people with obesity, this indication may affect insurance coverage decisions.

Insurance Type	Coverage Rate	Average Copay	Notes
Commercial Insurance	~65% of plans	$25-150/mo	Savings card available
Medicare Part D	Tier 3/4	$50 cap (mid-2026)	GENEROUS program
Medicaid	Varies by state	$4-10	Prior auth BMI>35
Employer Plans	Varies	$100+ deductible	90-day supply options

Pharmacy Price Comparison Table USA

Cash prices for Zepbound vary significantly by pharmacy. According to GoodRx, patients can save up to 22% off the average retail price using coupons. The actual retail price of Zepbound can vary by pharmacy, and price-shopping can help save on costs. For the absolute lowest prices, LillyDirect vials at $299 (starter dose) offer the best value for self-pay patients.

Pharmacy	Cash Price (Pens)	GoodRx Price	LillyDirect Vials	Notes
Costco	$1,060	$995	$299-449 shipped	90-day $2,985
CVS	$1,120	$1,020	N/A	ExtraCare 5%
Walgreens	$1,100	$1,020	N/A	MyWalgreens $25
Walmart	$1,150	$1,045	$299-449 pickup	LillyDirect partner
Rite Aid	$1,130	$1,020	N/A	Wellness card

 

In October 2025, LillyDirect partnered with Walmart to offer in-store pickup for Zepbound vials at the same direct-to-consumer pricing, expanding convenient access for those who prefer not to use home delivery.

Zepbound Canada Price 2026

Zepbound was approved by Health Canada and became available in Canadian pharmacies as of July 2025. Following a December 2025 price reduction, the Canadian list price for a four-week supply was lowered This represents approximately 45-55% savings compared to US list prices.

Dose	USD Price/Month	Notes
2.5-5 mg	$559.99	Starter doses
7.5-10 mg	$699.99	Maintenance doses
12.5-15 mg	$799.99	Higher doses

Cross-border pharmacy restrictions have tightened in 2026, so patients should verify import requirements before ordering from Canada.

Zepbound Savings Card & Lilly Programs

The Zepbound Savings Card is available for commercial insurance holders and can significantly reduce costs. According to Eli Lilly’s official savings page, eligible patients with commercial insurance coverage for Zepbound can pay as low as $25 for a 1-month, 2-month, or 3-month prescription fill. For patients with commercial insurance that does not cover Zepbound, the savings card can lower costs to as low as $499 per month for single-dose pens.

Eligibility requirements for the Zepbound Savings Card include: having a valid prescription for an FDA-approved use, being enrolled in a commercial drug insurance plan, being a US resident, and being 18 years of age or older. Government insurance beneficiaries (Medicare, Medicaid, TRICARE, VA) are not eligible for the savings program.

The Lilly Cares Foundation Patient Assistance Program may provide Zepbound free of charge to qualifying patients with income below 400% of the federal poverty level (approximately $58,000 for a single individual). This program requires a 6-month approval process and documentation of financial need.

Medicare Coverage & Trump MFN Impact

Historically, Medicare has not covered weight loss drugs or medications prescribed solely to treat obesity and overweight. However, the Trump administration announced the GENEROUS model in November 2025, which ties Medicare GLP-1 prices to OECD lowest prices through Most Favored Nation (MFN) pricing.

Starting as early as April 2026 (with full rollout mid-2026), Medicare beneficiaries will pay no more than $50 per month for Zepbound when prescribed for obesity with related comorbidities (such as heart disease, kidney disease, or severe obesity), according to Eli Lilly’s press release. 

The Medicare price will be $245 per month (down from $1,086 list price), representing potential annual savings of over $10,000 for beneficiaries.

Plan Type	2026 Coverage	Patient Copay	MFN Impact
Part D Standard	Tier 3	$50 cap	$245 Medicare price
Medicare Advantage	55% cover	$50 cap	Price parity
Extra Help (LIS)	Full coverage	$9.45	Unchanged

 

Zepbound vs GLP-1 Competitors Cost

When comparing Zepbound to other GLP-1 medications for weight management, pricing and clinical efficacy are key considerations. Zepbound and Mounjaro contain the same active ingredient (tirzepatide) but are FDA-approved for different uses: Zepbound for weight loss and obstructive sleep apnea, Mounjaro for type 2 diabetes.

In clinical trials, people taking Zepbound lost an average of 15% to 21% of their body weight over 18 months, depending on dosage. The most significant weight loss with Zepbound occurs within the first 6 months, stabilizing after approximately one year. This places Zepbound among the most effective weight loss medications available.

Drug	USA List/Month	Canada CAD/Month	Savings Card
Zepbound 15mg	$1,086	$550-600	$25 w/ coverage
Mounjaro 15mg	$1,069	$420-600	$25 w/ coverage
Wegovy 2.4mg	$1,350	$800-1,100	Limited
Saxenda 3mg	$1,349	$900-1,200	$25 w/ coverage

LillyDirect Vials vs Prefilled Pens

Zepbound is available in single-dose vials and pre-filled pens, with the vials typically being a more affordable option for those paying cash or without insurance. In Q2 2025, approximately 35% of new Zepbound prescriptions were fulfilled through LillyDirect’s self-pay option, demonstrating the growing preference for the lower-cost vial format.

Format	Cost/Month	Dosing	Convenience
Vials 2.5mg	$299	Draw with syringe	Learning curve
Vials 5mg	$399	Draw with syringe	Provider training
Vials 7.5-15mg	$449	Draw with syringe	45-day refill req
Pre-filled Pens	$1,086	Auto-inject	User-friendly

Note: To maintain the $449 monthly price for doses 7.5 mg and above through the Zepbound Self Pay Journey Program, patients must complete their refill purchase within 45 days of the delivery date of their previous prescription.

How to Get Zepbound Cheapest 2026

Based on current pricing and savings programs, here are the most cost-effective ways to access Zepbound in 2026:

• Savings Card + Commercial Insurance: $25/month (82% of eligible commercial patients)
• LillyDirect Vials (Self-Pay): $299 starter dose, $449 maintenance doses
• Costco GoodRx: $995 for pens (90-day supply $2,985)
• Medicare MFN (Mid-2026): $50 copay projected
• Canada (USD equivalent): $217-435 depending on dose

Pro Tip: LillyDirect + vial delivery bypasses pharmacy markups entirely and offers the lowest self-pay prices. To begin the process of getting a prescription for Zepbound, you can start a virtual visit through a telehealth service, where a licensed clinician will review your health history and medical history to determine if you are eligible.