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Saxenda Side Effects & What Might Help In Managing Them

Published On: April 4, 2025
Saxenda Side Effects

So you’re thinking about starting Saxenda or have just begun taking it. In either case, it is super important to know about possible side effects. Knowing what could happen helps you prepare for it and differentiate between what’s normal and what is not. This blog will cover common side effects,  like nausea or constipation, that people experience on Saxenda, along with the tips on how to manage them. 

We will also tell you when it is necessary to see a doctor. This way, you’re in control of these symptoms and well-equipped to make informed decisions about your health. 

Side Effects of Saxenda: What to Expect?

Now, it’s important to remember that not everyone experiences these, and often, they’re mild and temporary. Saxenda works by mimicking a natural hormone in your body called GLP-1, which helps regulate appetite and digestion. Because it is affecting your digestive system, many of the common side effects are related to your gut. 

We’re talking about nausea (the most common, especially when starting the dose), constipation, diarrhea, or general tummy discomfort. It is like your body is getting used to the new signals. You might also experience some reactions like redness or itching on injection sites  where you inject, but these are usually pretty minor. Other possible side effects include headaches, fatigue, and dizziness which are discussed later on in this article. 

Gastrointestinal Issues on Saxenda

Saxenda works by mimicking glucagon-like peptide-1 (GLP-1), which slows down digestion. This mechanism, while helpful for weight management, can lead to various gastrointestinal (GI) side effects.  

Nausea and Vomiting (Most Common)

These are the most frequently reported side effects of Saxenda. This is primarily due to the delayed gastric emptying caused by the medication. Food stays in the stomach for longer, which can trigger feelings of nausea and, in some cases, vomiting.  

To manage nausea, several strategies can be effective. 

  • Eating smaller, more frequent meals can prevent the stomach from becoming overly full.
  • Opting for bland foods like plain toast, crackers, or rice can also be helpful.
  • Ginger, in various forms such as ginger tea or ginger candies, is a well-known natural remedy for nausea. 

If these measures don’t provide relief, talk to your doctor; they might suggest anti-nausea medication.  

Diarrhea and Constipation

Saxenda can cause both diarrhea and constipation, sometimes alternating between the two. Diarrhea can occur due to the changes in digestion and the increased fluid content in the intestines. Conversely, slowed digestion can lead to constipation.  

Managing these issues often involves dietary adjustments. 

  • Increasing fiber intake through foods like fruits, vegetables, and whole grains can help regulate bowel movements. 
  • Staying well-hydrated by drinking plenty of water is also essential, especially if experiencing diarrhea. 

If constipation persists, a mild over-the-counter laxative, after consulting a healthcare professional, might be considered.  

Abdominal Pain and Discomfort

These GI side effects can arise from the altered digestive processes caused by Saxenda and can result in bloating, gas, or general abdominal discomfort.  

To minimize abdominal discomfort, eat slowly and consume smaller portions. This will allow the digestive system to process food more efficiently. Avoid greasy or spicy foods, as these further irritate the stomach.  

When to See a Doctor for Saxenda Side Effects?

The key takeaway is to be aware of these possibilities but don’t let them scare you. Most people manage them just fine, and we will review some tips on how to do that. 

While Saxenda can be a helpful for weight management, it’s essential to be able to recognize the more serious potential issues.

Serious Side Effects of Saxenda

Although rare, some serious side effects might require immediate medical attention. These include pancreatitis (inflammation of the pancreas), gallbladder problems, kidney issues, severe allergic reactions (like rash, swelling, or difficulty breathing), and, in very rare cases, depression or suicidal thoughts. 

If you experience severe abdominal pain, persistent vomiting, yellowing of the skin or eyes, signs of an allergic reaction, or any changes in your mood or thoughts, it’s crucial to contact your doctor or seek emergency medical help right away. These aren’t things to brush off.  

Low Blood Sugar (Hypoglycemia)

Saxenda can increase the risk of low blood sugar, especially if you’re also taking other medications for diabetes, like insulin or sulfonylureas. This is because both Saxenda and these medications can lower blood sugar levels. 

Symptoms of hypoglycemia include sweating, shakiness, dizziness, confusion, and rapid heartbeat. If you experience these symptoms, it is essential to check your blood sugar with a monitor. You must consume some fast-acting carbohydrates, like juice or glucose tablets. Contact your doctor if your blood sugar remains low.  

Long-Term Use

While Saxenda can be effective for long-term weight management, it is important to be aware of its potential long-term effects. Some studies have suggested a possible association with increased heart rate, and there can be changes in mood for some individuals. 

Because of these possibilities, regular check-ups with your doctor are essential to monitor your overall health and address any potential long-term issues.  

Underlying Medical Conditions

Here is the most crucial part: Saxenda may interact with certain medications or worsen existing medical conditions. 

For example, people with a history of medullary thyroid carcinoma (a type of thyroid cancer) or multiple endocrine neoplasia syndrome type 2 (MEN 2) should not use Saxenda. That is why it is absolutely vital to disclose all your medical conditions and medications, including over-the-counter drugs and supplements, to your doctor before starting Saxenda. This allows them to assess if Saxenda is safe for you and to adjust your treatment plan if necessary.

Final Words From Pandameds.com

So, there you have it! Most side effects are temporary and manageable with a few tweaks to your routine or over-the-counter remedies. But if anything feels concerning or just plain bothersome, do not hesitate to consult your doctor. 

Saxenda can be a great tool, but using it safely and effectively is key. Here at Pandameds.com, we work towards empowering you to make informed decisions about your health. So keep this information in your back pocket, and remember, a healthy dose of communication with your doctor goes a long way!

Disclaimer: This information is intended for general knowledge and informational purposes only and does not constitute medical advice. Always consult with a healthcare professional for personalized guidance.

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